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Three poliovirus serotypes (PV1, PV2, and PV3) have been identified. Poliovirus isolates are grouped into three categories: 1) WPVs (current WPVs are genetically unrelated to any vaccine strain), 2) vaccine related polioviruses (VRPVs; 1 divergent [PV1 and PV3] or >0.6 divergent [PV2] from the corresponding OPV strain) (2). VDPVs are further categorized as 1) when evidence of person to person transmission in the community exists; 2), which are isolated from persons with primary, B cell immunodeficiencies (defects in antibody production); and 3) ambiguous VDPVs (), which are either clinical isolates from persons with no known immunodeficiency and no evidence of transmission or sewage isolates whose source is unknown (2)..

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