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I'd also like to after I just do a quick reminder for everyone in the room what this study is about I'll make a couple of other comments about her background, then we'll move directly on to her presentation.For those of you who have seen this before apologies, those who haven't, it's a busy slide, but this is just to remind everyone that we have a two part study that is ongoing, only the first part or part one which is a Phase 2 single arm study open label study in MDS and lower risk MDS has been ongoing at the moment. And as we'll talk about at the end of this we're actually in expansion phase of that.Eventually assuming those data turn out appropriately, the study is designed to go to a Phase 3 randomized, double blind, placebo controlled study but we have not yet started that. So, everything that Dr.

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