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In any case PRTK has not suggested that the trial is powered to produce statistical non inferiority (rightly so, 200 patients probably won't do it). Since the trial is only a phase 2 study, such a result isn't necessary; rather, the trial should serve to inform the design of a phase 3 study including patient numbers needed to clear that hurdle (demonstrating non inferiority) when it matters.Figure 6: Results from a trial of short course nitrofurantoin vs trimethoprim sulfamethoxazole (TMP SMX) in acute uncomplicated cystitis which enrolled 338 women, of whom 308 were included in the analysis. A 79% rate of overall clinical cure for TMP SMX vs 84% for nitrofurantoin produced a difference of 5%, iPhone x case but the 95% confidence interval on that difference spans 13% to 4%.

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