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Lack of sleep or sleep disturbance can cause shifts in hormones and stress the entire system. Skimping on shut eye has been linked to hormonal problems leading to weight gain, and now a 2014 study in the Journal of Clinical Sleep Medicine has shown a positive association between sleep disturbance from moderate to severe sleep apnea and cancer incidence. The International Agency for Research on Cancer has classified the "shift leading to a disruption of circadian rhythm as probably carcinogenic to humans." When the circadian rhythm is disrupted in rotating shift workers or people who work at night, hormonal shifts in melatonin have been studied in relation to incidence of certain types of cancers.
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