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Though different in the specifics, the core idea is the same: to remove the inflammatory mediators and/or toxins from the blood in the hope that their removal will reduce or disrupt the deadly inflammation sufficiently to save the patients' lives. Spectral's device (PMX) removes endotoxin while CytoSorbents' device (CytoSorb) removes cytokines, free hemoglobin, etc. Patient selection was unclear and differed with the various techniques.

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