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The third one is our first line renal iPhone Cases cancer opportunity and the fourth one is gastric cancer.I'm thinking these four, because while we have a much broader program these are four opportunities two things in common. First of all they are billion dollar plus, big sales opportunities for our franchise and second they depend on data readouts, we have already seen or we are likely to see in the next 12 to 18 months. So these are just examples of relatively large number of meaningful catalyst for the Company again in the next 12 to 18 months.And third comment I would like to say that our pipeline has probably never been more promising and stronger with a number of programs that are advancing towards registrational studies, both in oncology and outside of oncology.
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